For an oocyte for being Prepared for fertilization and expansion into an embryo, the proper set of genes has to be turned on. Namekawa suspected that this pre-programming of your oocyte genome takes place in various phases — the main one starting within the time a woman is born. He thought that chromatin remodeling proteins did much of the get the job done, by shifting spools around.
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Using the GCRLE grant, Munakata and Namekawa will seem more closely at how oocytes are genomically primed and saved for later use. They'll look into the purpose of a chromatin remodeler in oocyte survival and fertility.
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